Evolution: Enhanced Footing for Snake Limb Development
نویسندگان
چکیده
Two groups have studied the loss of limbs in snake evolution by focusing on a long-distance cis-acting enhancer of Sonic Hedgehog. They find a progressive degeneration of binding sites for key transcription factors, mirroring the progressive limblessness occurring in these reptiles.
منابع مشابه
Developmental, genetic, and genomic insights into the evolutionary loss of limbs in snakes.
The evolution of snakes involved dramatic modifications to the ancestral lizard body plan. Limb loss and elongation of the trunk are hallmarks of snakes, although convergent evolution of limb-reduced and trunk-elongated forms occurred multiple times in snake-like lizards. Advanced snakes are completely limbless, but intermediate and basal snakes have retained rudiments of hindlimbs and pelvic g...
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The evolution of body shape is thought to be tightly coupled to changes in regulatory sequences, but specific molecular events associated with major morphological transitions in vertebrates have remained elusive. We identified snake-specific sequence changes within an otherwise highly conserved long-range limb enhancer of Sonic hedgehog (Shh). Transgenic mouse reporter assays revealed that the ...
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ورودعنوان ژورنال:
- Current Biology
دوره 26 شماره
صفحات -
تاریخ انتشار 2016